Tuesday, April 16, 2019
Day 1 Moderator - TBA

8:00AM   WELCOME / CONFERENCE OVERVIEW 
Edward Calabrese, Conference Director, UMass/Amherst

PLENARY SESSION

8:30AM
Hormesis: It's Impact on Biology, Toxicology, and Medicine 
Walter J. Kozumbo, Hormesis Project, University of Massachusetts, Amherst, MA

9:15AM
Radiation Hormesis: Its Significance and Applications 
Douglas Boreham, North Ontario School of Medicine, Sudbury, Ontario, Canada

10:00AM  BREAK

10:30AM
Metabolic Management of Cancer 
Thomas Seyfried, Biology Department, Boston College, Chestnut Hill, MA

11:15AM
From Jumping Genes to Genomic Instability: The Contributions of Barbara McClintock to Low Dose Radiation Biology and Toxicology 
Carmel Mothersill, Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

12:00PM  LUNCH, AMHERST ROOM 10TH FLOOR CAMPUS CENTER

SESSION I: EXERCISE

1:30PM
Digitizing Physical Activity Dose: Step Counting and Cadence Tracking 
CatrineTudor-Locke, Department of Kinesiology, School of Public Health, UMass, Amherst, MA

2:00PM
Exercise Induced Hormesis in Skeletal Muscle Health 
Ji Li, Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota, Minneapolis, MN

SESSION II: INTERMITTENT FASTING

2:30PM
Harnessing the Benefits of Intermittent Fasting by Targeting Lysosomes 
Abhinav Dwan, Department of Internal Medicine, Washington University, St. Louis, MO

3:00PM  BREAK

3:30PM
Caloric Excess or Restriction and the Human Inflammasome 
Michael Sac, Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD

5:30 - 6:30PM  POSTER SESSION AND SOCIAL, 10TH FLOOR CAMPUS CENTER

6:30PM  DINNER AND AWARDS, AMHERST ROOM 10TH FLOOR CAMPUS CENTER
Dinner Speaker Paul Shelby
The Selby-Russell dispute regarding the non-reporting of critical data in the Mega-Mouse Experiments of Drs. William and Liane Russell that spanned many decades: What happened, Current status, and Some ramifications.  

Wednesday, April 17, 2019
Day 2 Moderator - TBA

SESSION III: ENHANCING RESILIENCE

8:00AM
Biological Resilience 
Rehana K. Leak,  Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA

8:30AM
Remote Ischemic Conditioning: Trials, Tribulations and Clinical Translation 
Karin Przyklenk, Cardiovascular Research Institute, Wayne State University School of Medicine, Detriot, MI

9:00AM
Remote Ischemic Conditioning for Stroke and Vascular Dementia: An Exercise Mimetic? 
David Hess, Department of Neurology, Medical College of Georgia, Augusta, GA

9:30AM
Endoplasmic Reticulum Stress: Its Role in Adaptive Response 
Danilo Medinas, Cellular and Molecular Biology, University of Chile, Santiago, Chile

10:00AM  BREAK and HOTEL CHECK-OUT

10:30AM
Biomarker Development for Aerobic Exercise: Applications for Assessing Performance and Pathology 
Michael Moto, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

11:00AM
Stress Inducible Evolution from Bacteria to Cancer 
Susan M. Rosenberg, Dept. of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

11:30AM   CONFERENCE CLOSING REMARKS
Colin Seymour, Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

12 - 2:00PM  LUNCH, AMHERST ROOM 10TH FLOOR CAMPUS CENTER

Click here to download the preliminary program.

Call for Posters   
We invite you to submit an abstract for poster presentation at the conference. The conference will address a multidisciplinary and mechanistic focus in toxicology, medicine, pharmacology, radiation, and risk assessment for dose-response relationships.

Areas of Interest

• Pre- Post- Conditioning: Alzheimer’s Disease/Dementia; Parkinson’s Disease; Depression and PTSD; Concussions/Traumatic Brain Injury; Improving Surgical Outcomes; Stroke/Cardiovascular Disease; Glaucoma; Stem Cell Transplantation Therapy
• Healthy Lifestyles, Aging and Life Extension: Intermittent Fasting; Exercise; Chemical/Nutritional Supplements; Low Dose Radiation and Longevity; Adaptive response-based cosmetics
• Enhancing Human Performance: Cognition; Endurance, Strength and Speed; Fatigue/Jet Lag: Prolong Onset/Speed Up Recovery; Wound Healing Acceleration - skin, tendon, muscle, bone, and vascular

Deadline: The deadline for abstract submissions for the Dose-Response 2019 Conference poster session is January 31, 2019

For abstract submission guidelines please email Mary B. Glavin and mbglavin@umass.edu. 

Driving to Campus
From the South, via I-91 North
Travelers have a choice of two routes:

• Take Exit 19 in Northampton: From the exit ramp, turn right onto Route 9 and go approximately 4.5 miles to Route 116 North. Turn left onto 116 and go one mile to the UMass Exit. Stay to the right as you exit. At the first set of traffic lights turn left onto Commonwealth Avenue. Travel on Commonwealth Avenue until you reach the next set of traffic lights. Turn right onto Campus Center Way and travel up the hill to the Campus Center Parking Garage entrance.
• Take Exit 24 in Deerfield: At the stop sign at the top of the ramp, turn right (north) onto Routes U.S. 5/10/116, and immediately turn right again at the traffic lights onto Route 116 South. Follow Route 116 South for eight miles to the UMass exit. Turn left at the stop sign. At the first set of traffic lights turn left onto Commonwealth Avenue. Travel on Commonwealth Avenue until you reach the next set of traffic lights. Turn right onto Campus Center Way and travel up the hill to the Campus Center Parking Garage entrance.

From the North, via I-91 South
Follow I-91 to Exit 25 in Deerfield. At the end of the ramp turn left and follow the road to the intersection. Turn right onto Routes 5 & 10 South. Go one mile, turn left onto Route 116 South. Following Route 116 South for eight miles to the UMass exit. Turn left at the stop sign. At the first set of traffic lights turn left onto Commonwealth Avenue. Travel on Commonwealth Avenue until you reach the next set of traffic lights. Turn right onto Campus Center Way and travel up the hill to the Campus Center Parking Garage entrance.

From the North, via I-93 South
Follow I-93 to I-495 South. Follow to Route 2 West. Continue on Route 2 to U.S. 202 South. Follow for about 15 miles to the blinking light at the Pelham exit marked “Route 9 and 116 Amherst.” Turn right and follow for seven miles to Amherst center. Follow signs to UMass. 

From the East or West, via I-90 
Travelers have a choice of four routes:

• Off Exit 8 (Palmer/Ware): Follow Route 32 South to Palmer; take Route 20 West to Route 181 North into Belchertown, and then Route 9 West to Amherst. Follow signs to UMass.
• Off Exit 7 (Ludlow): Follow Route 21 North to U.S. 202 North to Route 9 West to Amherst center. Follow signs to UMass.
• Off Exit 5 (Chicopee): Follow Route 33 North to Route 116 North to Amherst center. Turn left at the light onto Route 9 West. Follow signs to UMass.
• Off Exit 4 (West Springfield): I-91 North to Exit 19 to Route 9 East to Amherst. Follow signs to UMass.

By Plane
If you are traveling to Amherst by plane, the closest airport is Bradley International Airport in Windsor Locks, Connecticut (near Hartford). This airport is approximately 45 miles from the UMass campus. Logan Airport in Boston is approximately 90 miles from the UMass campus. Both airports feature car rental agencies and a variety of shuttle services, including Valley Transporter (413-253-1350) and Seemo Shuttle (413-586-1120 or 800-908-2829).

By Bus
The Amherst area is serviced by Greyhound, Peter Pan Bus Lines and the Pioneer Valley Transit Authority. Based on the service you select and route availabilities you should take a bus to Amherst UMass if at all possible instead of Amherst Center (Amherst Center is about 1.5 miles from the UMass Campus). Please be sure to review bus schedules and campus maps before your arrival as both the area and the campus can be confusing to navigate if it is your first time here. 

Conference Location   
The conference will be held at the University of Massachusetts Amherst Murray D. Lincoln Campus Center. The Campus Center is located at 1 Campus Center Way, Amherst MA 01003. For travel information, please click the Getting to Campus tab above.

Registration will be held on the first floor concourse of the UMass Murray D. Lincoln Campus Center from 7:30 - 10:30AM on Tuesday, April 16. After entering the Campus Center take the escalators or elevators down to the first floor, following the signs directing you to registration. Registration will be located at the large desk outside of room 163/165. Please be sure to come to the registration desk to pick up your conference materials and, if necessary, a parking pass to the Campus Center Parking Garage (see below). If you arrive after 10:30AM, or if you need any assistance throughout the event, you may come to the Conference Registration Office located in Room 810 on the eighth floor of the Campus Center.

Parking   
Parking is available for all attendees in the Campus Center Parking Garage, located at 1 Campus Center Way, Amherst, MA, 01003. Campus Center Way is off of Commonwealth Avenue, across the street from the Mullins Center. After turning onto Campus Center Way stay to the left to go up the hill - you will see the garage entrance on your right. Take a gate ticket and follow the "Hotel UMass/Campus Center" signs to park down on Level 2. There is a marked walkway into the Campus Center (right at the Parking Services Office). Follow the signs to the registration desk.

The Campus Center Parking Garage is now automated! After you park, take your gate ticket inside with you. If you are staying at Hotel UMass, provide your gate ticket to the hotel desk clerk at check-in. The desk clerk will validate your gate ticket, which will provide you with complimentary parking. Keep your gate ticket in a secure spot for the duration of your stay and take it with you each time you exit - as you drive out you will need to insert your validated gate ticket into the kiosk located at the garage exit to lift the exit gate. If you are not staying at Hotel UMass, pick up a parking coupon at the registration desk. As you leave for the day (but before you get to your car) stop at a pay station with this parking coupon and the gate ticket you received as you drove in. Enter your gate ticket in the pay station and, when prompted, scan the QR code on the parking coupon. This will give you complimentary parking and validate your gate ticket for the day. As you drive out of the garage enter your validated gate ticket at the exit to raise the gate. Repeat this process for each day you attend. Note: you should only stop at the pay station when you are about to leave for you day.

On-Campus & Area Lodging 
The Amherst area is full of many wonderful lodging options, including those below. Please click here for a full listing. We recommend attendees stay at Hotel UMass, located right in the Campus Center just an elevator ride away from conference activities.

Amherst

• Hotel UMass - 413-549-6000 - reference group code DR419C when completing a reservation to receive the discounted group rate
• Allen House Inn - 413-253-5000
• Black Walnut Inn - 413-549-5649
• Lord Jeffrey Inn - 413-253-2576
• University Lodge - 413-256-8111

Hadley

• Econo Lodge - 413-582-7077
• Hampton Inn - 413-586-4851
• Holiday Inn Express - 413-582-0002
• Howard Johnson - 413-586-0114
• Courtyard by Marriott - 413-256-5454

Deerfield

• Deerfield Inn - 413-774-5587
• Red Roof Inn - 413-665-7161

For Program Related Questions:   
Contact Mary Glavin (413-545-3164 or mbglavin@umass.edu). For additional details, be sure to take a look at the preliminary program. 

For Registration or Payment Related Questions:   
Contact the UMass Conference Services Registration Office at 413-577-8102 or registration@umass.edu.